⮝ Full datasets listing
PXD073602-1
PXD073602 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Polygonatum sibiricum Polysaccharide Modulates Gut Microbiota and Bile Acid Homeostasis to Ameliorate Colitis |
| Description | Inflammatory bowel disease (IBD) relates to gut microbiota dysbiosis, bile acid (BA) disturbance and intestinal barrier impairment. We purified a fructose-dominant (Fru 93.63%) low-molecular-weight Polygonatum sibiricum polysaccharide (PSP). In 3% DSS-induced colitis in C57BL/6 mice, PSP (400 mg/kg/day) alleviated symptoms. Multi-omics showed PSP reversed DSS-induced disorders, regulated BA biosynthesis, restored barrier function and mitigated colitis, supporting its IBD intervention potential. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-26 |
| AnnouncementXML | Submission_2026-01-26_17:09:13.717.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jia Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-26 17:07:53 | ID requested | |
| ⏵ 1 | 2026-01-26 17:09:14 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: polysaccharide,colitis,Polygonatum sibiricum Polysaccharide |
Contact List
| Peng Huang | |
|---|---|
| contact affiliation | Hunan Agricultural University |
| contact email | 83124875@qq.com |
| lab head | |
| Jia Wang | |
| contact affiliation | Hunan Agricultural University |
| contact email | 13770321807@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
