PXD073484-1

PXD073484 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Ubiquitin diGly site ampping on ZNFX1 autoubiquitination reactions
Description	This experiment aimed to characterise ubiquitin chain linkage preferences generated and autoubiquitination sistes during ZNFX1 E3 reactions using diGly remnant mass spectrometry. GlyGly-modified lysine residues were identified as a qualitative proxy for ubiquitin linkage types. Spectral counts of rank-1 GlyGly-modified peptides were used to infer relative linkage abundance. Data interpretation was qualitative in nature, with no quantitative normalisation or statistical comparison applied.
HostingRepository	PRIDE
AnnounceDate	2026-05-22
AnnouncementXML	Submission_2026-05-22_10:51:50.932.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Satpal Virdee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-23 14:52:53	ID requested
⏵ 1	2026-05-22 10:51:51	announced

Publication List

Squair DR, Rivers E, Sowar H, Balci A, Harmo R, Wright DJ, Beniwal G, Soetens M, Mathur S, Tollervey A, Wood NT, Pao KC, Stanton C, Fletcher AJ, Virdee S, ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA. Mol Cell, 86(6):1164-1181.e12(2026) [pubmed]
10.1016/j.molcel.2026.02.015;

Squair DR, Rivers E, Sowar H, Balci A, Harmo R, Wright DJ, Beniwal G, Soetens M, Mathur S, Tollervey A, Wood NT, Pao KC, Stanton C, Fletcher AJ, Virdee S, ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA. Mol Cell, 86(6):1164-1181.e12(2026) [pubmed]

10.1016/j.molcel.2026.02.015;

Keyword List

submitter keyword: ZNFX1 ubiquitin chains

submitter keyword: ZNFX1 ubiquitin chains

Contact List

Satpal Virdee
contact affiliation	MRC Protein phosphorylation unit, University of Dundee
contact email	s.s.virdee@dundee.ac.uk
lab head
Satpal Virdee
contact affiliation	University of Dundee
contact email	s.s.virdee@dundee.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD073484
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD073484

PRIDE project URI

Repository Record List

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