PXD073466-1

PXD073466 is an original dataset announced via ProteomeXchange.

Title	Comparative Proteomic Profiling of Tau-Knockout and Wild-Type Mouse Hippocampus
Description	Mitochondria fuse, divide, and interact with other organelles to adjust cellular fitness while they provide energy to sustain neuronal activity and health. In contrast to plethora of evidence reporting that accumulation of pathological Tau damages mitochondria function promoting neurodegeneration, there is limited knowledge about the physiological role of Tau on the maintenance of mitochondrial homeostasis. Our mice and C. elegans studies provide multiscale evidence that loss of Tau or its nematode homolog, PTL-1, enhances mitochondrial function and mitochondria quality control promoting a profusion state via mitofusins, that leads to reduced vulnerability to mitochondria stress. Overall, our findings provide solid evidence about the fine-tuning role of Tau protein on mitochondrial function and dynamics in neurons based on two different organisms.
HostingRepository	PRIDE
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-15_06:56:39.929.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Samiotaki
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-23 10:28:35	ID requested
⏵ 1	2026-06-15 06:56:40	announced

Dataset with its publication pending

submitter keyword: DIA, Mus musculus, hippocampus, quantitave proteomics,Tau knockout, Mapt knockout

Ioannis Sotiropoulos
contact affiliation	ExoBrain - Laboratory of Brain Exosomes & Pathology Institute of Biosciences & Applications NCSR "Demokritos" T. Patriarchou Grigoriou & Neapoleos 15341 Athens, Greece
contact email	ioannis@bio.demokritos.gr
lab head
Martina Samiotaki
contact affiliation	Protein Analysis Laboratory B.S.R.C. "Alexander Fleming", Alexander Fleming Street 34 16672, Vari, Greece
contact email	samiotaki@fleming.gr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD073466

PRIDE project URI

• PRIDE
  1. PXD073466
     1. Label: PRIDE project
     2. Name: Comparative Proteomic Profiling of Tau-Knockout and Wild-Type Mouse Hippocampus