PXD073431-1

PXD073431 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of nanoscale-engineered silk fibroin treated Sprague-Dawley BMSC
Description	Inspired by the native biomineralization mechanisms of the bone matrix, we developed a growth factor-free, nanoscale-engineered silk fibroin (NESF) hydrogel to enhance in situ biomineralization and promote effective endogenous bone regeneration. By modulating SF nanofiber length to enrich acidic groups, the hydrogel acquired an increased negative surface charge, providing initial physical cues that effectively attracted inorganic ions and promoted Ca2+-PO43- nucleation, resulting in a 6.09-fold enhancement in biomineralization. These intrinsic chemical modifications further boosted the biological activity of the NESF hydrogel by promoting the adhesion and proliferation of BMSCs, and facilitated osteogenic differentiation by elevating intracellular Ca2+ influx and activating the MAPK/ERK signaling pathway.
HostingRepository	iProX
AnnounceDate	2026-01-22
AnnouncementXML	Submission_2026-01-23_00:42:35.551.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaxiang Li
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-23 00:41:01	ID requested
⏵ 1	2026-01-23 00:42:36	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: proteomic, silk fibroin, nanoscale engineering,

submitter keyword: proteomic, silk fibroin, nanoscale engineering,

Contact List

Full Dataset Link List

iProX dataset URI