⮝ Full datasets listing
PXD073403-1
PXD073403 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative proteomic analysis of human iPSC derived dopaminergic neurons reveals model specific pathological signatures in Parkinsons disease |
| Description | To overcome the limitations of traditional Parkinson s disease models, we employed human iPSC derived dopaminergic neurons as a human centric experimental platform. We established three in vitro models using MPTP, 6 OHDA, and alpha synuclein PFFs, subsequently performing TMT based quantitative proteomics to enable a direct, unbiased comparison across conditions. By synthesizing differential expression and functional enrichment data, we identified shared and model enriched proteomic signatures. Our findings provide a systematic proteome level reference framework, facilitating evidence based model selection for studying the diverse molecular mechanisms underlying PD pathology. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-04-09 |
| AnnouncementXML | Submission_2026-04-09_01:02:38.350.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Han-Byeol Kim |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-22 04:01:08 | ID requested | |
| ⏵ 1 | 2026-04-09 01:02:38 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: parkinson disease stem cell, DatasetType:Proteomics |
Contact List
| Min Seong Kim | |
|---|---|
| contact affiliation | Department of Integrative Bioscience and Biotechnology, Institute of Bioscience, Sejong University |
| contact email | Minseongkim@sejong.ac.kr |
| lab head | |
| Han-Byeol Kim | |
| contact affiliation | yonsei |
| contact email | existstar1@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000100551/ |
