PXD073360-1

PXD073360 is an original dataset announced via ProteomeXchange.

Title	Differential Proteomics of Ptl-1 KO and Control C.elegans
Description	Mitochondrial damage is a shared hallmark of brain aging and neurodegeneration. While pathological Tau mutations are known to impair mitochondrial dynamics and function, the physiological role of wild-type Tau in the maintenance of mitochondrial homeostasis remains poorly understood. Here, using C. elegans and mice lacking PTL-1, the nematode Tau-like homolog, and Tau respectively, we demonstrate that Tau deficiency enhances mitochondrial respiration, ATP production and mitophagy, promoting a pro-fusion mitochondrial network in neurons. Tau-deficient nematodes also display increased resistance to stressors, including heat and mitochondrial insults. Strikingly, loss of FZO-1, the mitofusin homolog, abolishes these effects, reducing mitochondrial function and stress resistance in PTL-1 deficient nematodes. Our findings reveal a conserved role for wild-type Tau in restraining mitochondrial fusion and activity via mitofusins, highlighting its contribution to mitochondrial quality control and cellular stress resilience.
HostingRepository	PRIDE
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-15_07:00:29.655.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Samiotaki
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: NEWT:6239;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-21 13:12:49	ID requested
⏵ 1	2026-06-15 07:00:30	announced

Dataset with its publication pending

submitter keyword: Quantitative proteomics, Ptl-KO,C.elegans

Konstantinos Palikaras
contact affiliation	Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece
contact email	palikarask@med.uoa.gr
lab head
Martina Samiotaki
contact affiliation	Protein Analysis Laboratory B.S.R.C. "Alexander Fleming", Alexander Fleming Street 34 16672, Vari, Greece
contact email	samiotaki@fleming.gr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD073360

PRIDE project URI

• PRIDE
  1. PXD073360
     1. Label: PRIDE project
     2. Name: Differential Proteomics of Ptl-1 KO and Control C.elegans