PXD073336-1

PXD073336 is an original dataset announced via ProteomeXchange.

Title	Retinal proteome changes mirror brain pathology and reveal synaptic and cytoskeletal dysfunction in Alzheimer’s disease
Description	Visual dysfunction is increasingly recognized as an important feature of Alzheimer’s disease, and substantial retinal changes have been documented across multiple studies. Yet the molecular changes underlying retinal neurodegeneration and which retinal protein signatures best track cerebral pathology remain incompletely defined. Here, we performed comprehensive mass spectrometry-based proteomics on paired retinal and hippocampal tissue from the same postmortem donors (8 AD, 8 non-demented controls) to identify disease-associated molecular signatures and assess their overlap between these tissues. Using a sequential dual-extraction protocol, differentially abundant proteins (DAPs) were identified with mixed-effects modeling. Functional enrichment and cell-type mapping based on single-cell retinal reference data assessed pathway alterations and cellular distribution of disease-associated proteins.
HostingRepository	PRIDE
AnnounceDate	2026-07-29
AnnouncementXML	Submission_2026-07-29_02:08:15.842.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jessica Santiago
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-21 03:37:37	ID requested
⏵ 1	2026-07-29 02:08:16	announced

10.1007/s00401-026-03054-x;

10.1007/S00401-026-03054-X;

submitter keyword: Alzheimer's,Retina,human

Malin Wennström
contact affiliation	Cognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
contact email	malin.wennstrom@med.lu.se
lab head
Jessica Santiago
contact affiliation	Lund University
contact email	jessica.dos_reis_santiago@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD073336

PRIDE project URI

• PRIDE
  1. PXD073336
     1. Label: PRIDE project
     2. Name: Retinal proteome changes mirror brain pathology and reveal synaptic and cytoskeletal dysfunction in Alzheimer’s disease