PXD073197-1

PXD073197 is an original dataset announced via ProteomeXchange.

Title	Soluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation
Description	The liver plays an important role in cardiovascular disease by amplifying systemic inflammation, while the underlying mechanisms remain to be defined. Soluble epoxide hydrolase (sEH) is a pro-inflammatory enzyme and pharmacological inhibition of sEH was shown to protect against various inflammatory diseases. In this study, we have identified a novel role of the liver, through expression of sEH, in the pathogenesis of abdominal aortic aneurysm (AAA). sEH expression and activity were markedly higher in mouse liver compared with aorta and further increased in the context of AAA. Pharmacological inhibition or hepatocyte-specific disruption of sEH prevented AAA formation in two animal models of AAA (systemic angiotensin II infusion and local aortic calcium chloride application), concomitant with reduced expression of complement C3 and serum amyloid A, liver-derived inflammatory factors causally linked to AAA formation. Interestingly, data from co-incubation of liver ex vivo with aorta identified galectin-3 secreted from the aneurysm-prone aorta that activate sEH in the liver. We also determined 12,13- dihydroxyoctadecenoic acid (DiHOME) and various circulating pro-inflammatory cytokines as a downstream mechanism potentially associated with hepatic sEH in the context of AAA. These novel findings provide direct evidence that bidirectional crosstalk between aorta and liver contributes to AAA via hepatic sEH.
HostingRepository	PRIDE
AnnounceDate	2026-04-07
AnnouncementXML	Submission_2026-04-07_09:37:13.611.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenbo Zhi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-17 16:52:43	ID requested
⏵ 1	2026-04-07 09:37:14	announced

10.1038/s42003-026-09765-x;

Kim DS, Horimatsu T, Ogbi M, Goo B, Shi H, Veerapaneni P, Chouhaita R, Cyriac N, Moses M, Prasad R, Cave S, Benson TW, Harb R, Aboud G, Sellers HG, Shivers M, Haigh S, Fulton DJ, Cs, á, nyi G, Huo Y, Long X, Coffey P, Lee R, Guha A, Zhi W, Young L, Zeldin DC, Hwang SH, Hammock BD, Weintraub NL, Kim HW, Soluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation in mice. Commun Biol, 9(1):(2026) [pubmed]

submitter keyword: angiotensin II, calcium chloride, liver, soluble epoxide hydrolase,abdominal aortic aneurysm

Kim, Ha Won
contact affiliation	Vascular Biology Center, Augusta University
contact email	hkim3@augusta.edu
lab head
Wenbo Zhi
contact affiliation	Augusta University
contact email	wzhi@augusta.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD073197
     1. Label: PRIDE project
     2. Name: Soluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation