⮝ Full datasets listing
PXD073097-1
PXD073097 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules |
| Description | Circular RNAs (circRNAs) accumulate with age, but their functional impact on aging remains elusive. In this study, we reveal a mechanism by which ribonuclease κ (RNASEK) prevents age-dependent circRNA accumulation by promoting its degradation. Through a genetic screen targeting ribonucleases, we identified RNASEK as a specific circRNA-cleaving ribonuclease. RNASEK is downregulated during aging, causing the age-dependent increase in circRNA levels. RNASEK is necessary and sufficient for lifespan extension and healthspan maintenance in Caenorhabditis elegans. Mammalian RNASEK also directly degrades circRNAs, and is required for preventing premature aging in cultured human cells and mice, indicating its evolutionarily conserved role. Notably, we demonstrate that circRNAs localize within stress granules, where RNASEK, in collaboration with HSP90, prevents toxic aggregation of circRNAs in aged organisms. Our study establishes RNASEK as a conserved regulator of aging and offers a framework for targeting circRNAs to mitigate age-associated diseases and to extend organismal healthspan |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-15 |
| AnnouncementXML | Submission_2026-02-24_17:52:16.830.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Seiun Kim |
| SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-15 00:17:20 | ID requested | |
| ⏵ 1 | 2026-02-24 17:52:17 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: C. elegans, LC-MS |
Contact List
| Seung-Jae V. Lee | |
|---|---|
| contact affiliation | Korea Advanced Institute of Science and Technology |
| contact email | seungjaevlee@kaist.ac.kr |
| lab head | |
| Seiun Kim | |
| contact affiliation | Korea Advanced Institute of Science and Technology |
| contact email | rlawjdfl2815@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
