⮝ Full datasets listing
PXD073039-1
PXD073039 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dual-omics analysis of the effect and mechanism of Jiedu Huayu granule in acute liver failure |
| Description | Acute liver failure is a severe condition with high mortality, requiring effective treatments. Jiedu Huayu Granule, a traditional Chinese medicine, shows protective effects, but its molecular mechanisms remain unclear. This study aims to investigate the therapeutic mechanisms of Jiedu Huayu Granule in acute liver failure using integrated transcriptomic and proteomic analyses. Results: Transcriptomic and proteomic profiling of rat models identified three key genes (Fth1, Necap2, and Prdx2) whose expression was upregulated in acute liver failure and subsequently downregulated by Jiedu Huayu Granule treatment. Animal and cellular experiments confirmed these expression changes. Bioinformatics analysis linked these genes to crucial pathways including ribosome function, chemokine signaling, and fatty acid metabolism. Molecular docking predicted stable binding interactions between active components of the herbal formula and the proteins encoded by these key genes. Conclusion: Jiedu Huayu Granule may exert its therapeutic effects against acute liver failure by modulating the expression of Fth1, Necap2, and Prdx2 and their associated pathways. These findings provide a molecular basis for the clinical application of Jiedu Huayu Granule and suggest novel potential targets for acute liver failure treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-14 |
| AnnouncementXML | Submission_2026-01-13_18:27:14.890.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Pei |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | TMT6plex reporter fragment |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-13 18:26:59 | ID requested | |
| ⏵ 1 | 2026-01-13 18:27:15 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Acute liver failure, Jiedu huayu granule, Transcriptome sequencing, Proteome sequencing, Molecular docking |
Contact List
| Yueqiao Chen | |
|---|---|
| contact affiliation | The First Affiliated Hospital of Guangxi University of Chinese Medicine |
| contact email | peihao2022@stu.gxtcmu.edu.cn |
| lab head | |
| Hao Pei | |
| contact affiliation | The First Affiliated Hospital of Guangxi University of Chinese Medicine |
| contact email | qw1304980268@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
