⮝ Full datasets listing
PXD073026-1
PXD073026 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of NEMO ubiquitination sites |
| Description | We demonstrate that K277E does not impair the ubiquitin-binding activity of NEMO; instead, it disrupts the HOIP–NEMO interface, destabilizes linear ubiquitin chain assembly complex (LUBAC) engagement in TNFR1 complex I, reduces linear ubiquitination, and promotes RIPK1 activation. We further identify a linked regulatory layer centered on inducible ubiquitination of NEMO at K285 that functions as a checkpoint restraining RIPK1. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-14 |
| AnnouncementXML | Submission_2026-08-13_19:51:09.641.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bing Shan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | ubiquitination signature dipeptidyl lysine |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-13 17:51:12 | ID requested | |
| ⏵ 1 | 2026-08-13 19:51:10 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: NEMO ubiquitination sites |
Contact List
| Junying Yuan | |
|---|---|
| contact affiliation | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences |
| contact email | junying_yuan@sioc.ac.cn |
| lab head | |
| Bing Shan | |
| contact affiliation | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences |
| contact email | shanbing@sioc.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
