PXD072955-1

PXD072955 is an original dataset announced via ProteomeXchange.

Title	ULK1-Driven Autophagy Modulation Alters Tumor-Promoting Pathways in Triple-Negative Breast Cancer
Description	This dataset supports a study investigating the proteomic consequences of pharmacological ULK1 modulation in triple-negative breast cancer. MDA-MB-231 cells were treated with the ULK1 activator LYN-1604 or the ULK1 inhibitor MRT68921 at EC50 concentrations (29.8 µM and 2.6 nM, respectively) for 24 h. Autophagic activity was evaluated by LC3 immunoblotting and fluorescence microscopy, and quantitative label-free LC–MS/MS was used to characterize global protein abundance changes following ULK1 activation versus inhibition. Differentially regulated proteins were further interpreted using interaction network analysis and pathway enrichment approaches to identify convergent tumor-related and immune-associated signatures linked to ULK1 perturbation.
HostingRepository	PRIDE
AnnounceDate	2026-03-09
AnnouncementXML	Submission_2026-03-08_17:48:24.615.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD072955
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Merve Gülsen Bal Albayrak
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-12 06:49:25	ID requested
⏵ 1	2026-03-08 17:48:25	announced

10.6019/PXD072955;

10.1007/s12032-026-03274-x;

Bal Albayrak MG, Yanar S, Korak T, Akpinar G, Kasap M, ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer. Med Oncol, 43(4):(2026) [pubmed]

submitter keyword: ULK1-Driven Autophagy Modulation Alters Tumor-Promoting Pathways in Triple-Negative Breast Cancer

Merve Gulsen Bal Albayrak
contact affiliation	Kocaeli University, Medical School, Department of Medical Biology,41001, Umuttepe, Kocaeli, Turkiye
contact email	mervegulsenbal@gmail.com
lab head
Merve Gülsen Bal Albayrak
contact affiliation	Kocaeli University
contact email	mervegulsenbal@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD072955

PRIDE project URI

• PRIDE
  1. PXD072955
     1. Label: PRIDE project
     2. Name: ULK1-Driven Autophagy Modulation Alters Tumor-Promoting Pathways in Triple-Negative Breast Cancer