PXD072701 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Temporal Multi-Omic Exploration of the Ventral Tegmental Area in Chronic Pain and Passive Coping Behaviors |
| Description | The comorbidity of chronic pain and mood disorders represents a significant clinical challenge, yet the underlying neurobiological mechanisms within key brain regions like the ventral tegmental area (VTA) remain poorly understood. To address this, a multidisciplinary approach was employed, combining proteomics, phosphoproteomics, and lipidomics with behavioral and immunohistochemical analyses in a mouse model of neuropathic pain induced by partial sciatic nerve ligation (pSNL). The data reveal a temporal shift in the VTA proteome, progressing from an early (1-week) signature of metabolic reallocation and increased protein synthesis to a late (4-week) state of excitotoxic stress, characterized by impaired energy metabolism, autophagy, and cytoskeletal breakdown. This late maladaptive state was associated with two convergent mechanisms promoting hyperexcitability: sex-specific remodeling of Kv7 potassium channel subunit expression in VTA dopamine neurons and a deficit in the endocannabinoid 2-arachidonoylglycerol (2-AG). The development of passive coping behavior, a correlate of negative affect, was associated with these molecular changes. Notably, pharmacological restoration of 2-AG signaling or potentiation of Kv7 channel function reversed the pain-induced passive coping behavior. These findings delineate a progressive molecular pathology in the VTA and identify the 2-AG and Kv7 systems as therapeutically-relevant nodes linking chronic pain to the development of these behavioral states. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-01 |
| AnnouncementXML | Submission_2026-04-30_23:05:49.830.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD072701 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Paul Langlais |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-06 01:27:19 | ID requested | |
| ⏵ 1 | 2026-04-30 23:05:50 | announced | |
Publication List
Keyword List
Contact List
| Arthur C. |
|---|
| contact affiliation | Department of Pharmacology, University of Arizona College of Medicine - Tucson |
| contact email | Ariegel@arizona.edu |
| lab head | |
| Paul Langlais |
|---|
| contact affiliation | University of Arizona |
| contact email | langlais@deptofmed.arizona.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072701
- Label: PRIDE project
- Name: Temporal Multi-Omic Exploration of the Ventral Tegmental Area in Chronic Pain and Passive Coping Behaviors
