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PXD072683-1
PXD072683 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The key roles of PMVK in hepatocarcinogenesis |
| Description | Metabolic reprogramming is a hallmark of cancer and a driver of hepatocellular carcinoma (HCC) initiation and progression. Through metabolic CRISPR screening, we identify phosphomevalonate kinase (PMVK), a critical kinase in the mevalonate pathway, as a key regulator in HCC stemness and lipid metabolism. Mechanistically, PMVK directly phosphorylates the transcription factor SP1 at Thr355, enhancing its DNA-binding affinity to increase transcriptional activity to promote the expression of genes involved in de novo lipid synthesis. Phosphorylated SP1 directly interacts with nuclear SREBP1/2, master factors of lipid biosynthesis, and facilitates the transcription of their target genes. Clinically, elevated levels of PMVK and phospho-SP1 (Thr355) are associated with poor prognosis in HCC patients. Functionally, genetic or pharmacologic inhibition of PMVK or SP1 significantly suppress HCC growth in cell lines, mouse models, and patient-derived organoids. These findings uncover a previously unrecognized PMVK–SP1 ax |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-05_19:17:12.479.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ruiyang Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | 4800 Plus MALDI TOF/TOF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-05 19:16:58 | ID requested | |
| ⏵ 1 | 2026-01-05 19:17:13 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: liver cancer stem cells, PMVK, lipid metabolism, SP1 phosphorylation |
Contact List
| Fei Xiao | |
|---|---|
| contact affiliation | Sun Yat-sen University |
| contact email | xiaof35@sysu.edu.cn |
| lab head | |
| Ruiyang Liu | |
| contact affiliation | Sun Yat-sen University |
| contact email | liury27@mail3.sysu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
