PXD072594 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nanostructures regulate cell adhesion behavior through mechanotransduction-mediated signaling pathways |
| Description | Nanotopography has a significant regulatory effect on cell adhesion behavior. We fabricated titanium alloy surfaces with titanium dioxide nanotubes using electrochemical anodization, which exhibited increased surface roughness and superhydrophilicity. Using single-cell force spectroscopy, we observed that the nanotubular structure altered the mechanical forces experienced at the cell-surface interface. Proteomic analysis revealed that Nesprin-1 protein transmits these signals to the intracellular core signaling system, leading to the upregulation and activation of GSK3β, STAT3, and related pathways. These events regulate cytoskeletal remodeling and adhesion complex assembly, thereby promoting cell adhesion. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_16:22:59.424.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shawn Shawn |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-02 22:13:50 | ID requested | |
| ⏵ 1 | 2026-05-24 16:23:00 | announced | |
Publication List
| 10.3390/jfb17040200; |
| Xiong C, Feng H, Lu L, Jing Z, Wang Y, Yang Y, Meng D, Zhang Y, Li W, Cai H, Nanotubes. J Funct Biomater, 17(4):(2026) [pubmed] |
Keyword List
| submitter keyword: mechanotransduction, mechanisms,TiO₂ nanotubes, single-cell force spectroscopy, cell adhesion |
Contact List
| Chenao Xiong |
|---|
| contact affiliation | Department of Orthopaedics, Peking University Third Hospital |
| contact email | xiongca@pku.edu.cn |
| lab head | |
| Shawn Shawn |
|---|
| contact affiliation | Department of Orthopaedics, Peking University Third Hospital |
| contact email | xiongca@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD072594 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072594
- Label: PRIDE project
- Name: Nanostructures regulate cell adhesion behavior through mechanotransduction-mediated signaling pathways
