PXD072537-1

PXD072537 is an original dataset announced via ProteomeXchange.

Title	YSHS activates PPAR signaling pathway to protect adenine-induced kidney injury
Description	Yi-Shen-Hua-Shi (YSHS) granule is a widely used drug for the treatment of chronic kidney disease in mainland China which could effectively improve renal function, reduce proteinuria, and alleviate renal pathological injury. Here, we explored the impact of YSHS in adenine-induced kidney injure model mice. The serological and renal histopathological changes suggested that YSHS could effectively improve renal function and renal tissue pathological injury Proteomics data indicated that YSHS remodeled the immune cells in kidney, inhibited fibrosis and inflammatory factor expression, and improved the lipid metabolism in renal cortex of model mice, which were confirmed by flow cytometry and biochemistry methods. In addition, the proteomics data showed that YSHS activated PPAR signaling pathway and elevated the expression of the downstream protein Klotho in kidney injury mice.
HostingRepository	iProX
AnnounceDate	2025-12-30
AnnouncementXML	Submission_2025-12-30_19:01:46.370.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liming Sun
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-30 19:01:25	ID requested
⏵ 1	2025-12-30 19:01:46	announced

Dataset with its publication pending

submitter keyword: adenine-induced kidney injury, PPAR signalling pathway, Klotho, Immune cell

Rong Zeng
contact affiliation	Center of excellence molecular cell science, CAS
contact email	zr@sibcb.ac.cn
lab head
Liming Sun
contact affiliation	University of Chinese Academy of Sciences
contact email	sunlm@ucas.ac.cn
dataset submitter

iProX dataset URI