PXD072468-1

PXD072468 is an original dataset announced via ProteomeXchange.

Title	Aberrant Amino Acid and Lipid Metabolism Disrupts the Endometrial Transition to Receptivity in Recurrent Implantation Failure
Description	This study comprehensively characterizes the proteomic alterations underlying endometrial dysfunction in recurrent implantation failure (RIF). Endometrial biopsies were collected longitudinally from 19 RIF patients and 19 matched controls across three critical menstrual cycle phases: mid-proliferative (MP), late-proliferative (LP), and mid-secretory (MS, LH+7). Proteins were extracted from approximately 15 mg of endometrial tissue, processed with trypsin digestion following reduction/alkylation, and analyzed using high-resolution data-independent acquisition (DIA) proteomics on a Thermo Scientific Orbitrap Astral mass spectrometer coupled with FAIMS Pro Duo interface. The dataset comprises 10,204 confidently identified proteins with high reproducibility (FDR ≤ 0.01).
HostingRepository	iProX
AnnounceDate	2026-05-18
AnnouncementXML	Submission_2026-07-22_19:54:55.941.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shen Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-28 19:22:11	ID requested
⏵ 1	2026-07-22 19:54:56	announced

Dataset with its publication pending

submitter keyword: Recurrent implantation failure, Endometrial receptivity, Proteomics

Metabolomics, Amino acid metabolism

Lipid metabolism

Shen Zhang
contact affiliation	The Second Affiliated Hospital of Chongqing Medical University
contact email	shenzhang@cqmu.edu.cn
lab head
Shen Zhang
contact affiliation	The Second Affiliated Hospital of Chongqing Medical University
contact email	shenzhang@cqmu.edu.cn
dataset submitter

iProX dataset URI