PXD072439-1
PXD072439 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Lactate-Mediated Cross-Talk between KRT15 and GPR68 drives Type 2 Immunity in ECRSwNP |
| Description | Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a refractory inflammatory disease driven by type 2 immunity, yet the mechanistic link between epithelial stress and immune activation remains elusive. Here, we identify a pathogenic expansion of KRT5⁺KRT15⁺ basal epithelial cells that undergo a metabolic switch to aerobic glycolysis, resulting in lactate overproduction and microenvironment acidification. This acidic niche activates the proton-sensing receptor GPR68 on infiltrating CD4⁺ T cells, triggering a Gq–IP1–IKK/ERK signaling cascade that promotes Th2 differentiation and cytokine release. Genetic ablation of GPR68 in CD4⁺ T cells or its pharmacological inhibition with a natural antagonist, 3-Bn-6-Bnid-DKP, ameliorated type 2 inflammation and pathology in vivo. Thus, we define a lactate-GPR68 axis that metabolically couples epithelial dysfunction to adaptive type 2 immunity in ECRSwNP |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-26 |
| AnnouncementXML | Submission_2025-12-26_01:12:13.489.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hongjie Du |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-26 01:11:51 | ID requested | |
| ⏵ 1 | 2025-12-26 01:12:14 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Lactate, ECRSwNP, GPR68, immunity |
Contact List
| Ming Xia | |
|---|---|
| contact affiliation | Shandong Provincial Hospital Affiliated to Shandong First Medical University |
| contact email | LCcheng211314@126.com |
| lab head | |
| Hongjie Du | |
| contact affiliation | Shandong Provincial Hospital Affiliated to Shandong First Medical University |
| contact email | duhongjie0316@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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