PXD072401-1

PXD072401 is an original dataset announced via ProteomeXchange.

Title	hiPSC-derived Mesendoderm cells LC-MSMS
Description	NONO deficiency in hiPSCs results in a distinct defect in early cardiomyocyte differentiation. Mechanistically, NONO interacts with HOXA1 and regulates the dynamic expression of key genes during early cardiomyocyte differentiation. ChIP-seq analysis reveals that NONO loss reduces HOXA1 occupancy at target genes, compromising its transcriptional regulation. Additionally, NONO and HOXA1 cooperatively activate the Wnt signaling.
HostingRepository	PRIDE
AnnounceDate	2025-12-28
AnnouncementXML	Submission_2025-12-28_01:10:07.200.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhiyu Feng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-24 07:55:18	ID requested
⏵ 1	2025-12-28 01:10:07	announced

Dataset with its publication pending

submitter keyword: LC-MSMS, Mesendoderm,hiPSC

Guoying Huang
contact affiliation	Children's Hospital of Fudan University
contact email	gyhuang@shmu.edu.cn
lab head
Zhiyu Feng
contact affiliation	children hospital of fudan university
contact email	fzy950924@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD072401

PRIDE project URI

• PRIDE
  1. PXD072401
     1. Label: PRIDE project
     2. Name: hiPSC-derived Mesendoderm cells LC-MSMS