PXD072344-1

PXD072344 is an original dataset announced via ProteomeXchange.

Title	Bacterial extracellular vesicles from Streptococcus mutans drive OSCC progression through β-catenin signaling
Description	This study aims to investigate the role of Streptococcus mutans–derived extracellular vesicles (SmEVs) in the progression of oral squamous cell carcinoma (OSCC). We integrated transcriptomics and DIA-based quantitative proteomics to systematically analyze changes in gene expression in CAL-27 cells after SmEV treatment, as well as the protein composition of SmEVs. Our findings demonstrate that SmEVs significantly activate the Wnt/β-catenin signaling pathway, and several vesicular proteins with potential β-catenin interactions were identified. In vivo experiments further confirmed that SmEVs promote tumor growth. This project provides a proteomic dataset of SmEVs in OSCC progression, offering a new molecular resource for understanding microbe–host interactions in cancer.
HostingRepository	iProX
AnnounceDate	2025-12-23
AnnouncementXML	Submission_2025-12-23_00:45:10.085.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong Fang
SpeciesList	scientific name: Streptococcus mutans; NCBI TaxID: 1309;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-23 00:44:38	ID requested
⏵ 1	2025-12-23 00:45:10	announced

Dataset with its publication pending

submitter keyword: Oral squamous cell carcinoma, Streptococcus mutans, extracellular vesicles, β-catenin

Yong Fang
contact affiliation	Harbin Medical University&Heilongjiang Province Key Laboratory of Immunity & Infection
contact email	yong.fang@ems.hrbmu.edu.cn
lab head
Yong Fang
contact affiliation	Harbin Medical University&Heilongjiang Province Key Laboratory of Immunity & Infection
contact email	yong.fang@ems.hrbmu.edu.cn
dataset submitter

iProX dataset URI