⮝ Full datasets listing
PXD072323-1
PXD072323 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Klotho-derived peptide 1 protects against acute kidney injury by directly targeting mitochondrial ATAD3A |
| Description | Acute kidney injury (AKI) is a clinical syndrome associated with severe morbidity and high mortality, for which there are currently no effective therapies. Aging, a state of Klotho protein deficiency, is an independent and prominent risk factor for AKI development and progression. Here we report that Klotho-derived peptide 1 (KP1), a small peptide that recapitulates the renoprotective potential of Klotho, effectively protected against AKI in mouse models induced by either cisplatin or ischemia-reperfusion injury. KP1 treatment improved kidney function, ameliorated structural damage, inhibited tubular cell apoptosis, and preserved mitochondrial integrity in both models. Mechanistically, KP1 could enter into kidney proximal tubular epithelial cells via endocytosis, directly targeted the mitochondrial protein ATPase family AAA domain-containing protein 3A (ATAD3A), and prevented its degradation and preserved its function. By interacting with the hypoxia inducible gene 1 (HIG1) domain family member 2A (HIGD2A) and maintaining its expression and function within the mitochondria, ATAD3A prevented cytochrome c release and inhibited caspase activation following injury, thereby alleviating renal tubular cell apoptosis. Collectively, these studies demonstrate that KP1 is a promising therapeutic for AKI by directly targeting and preserving mitochondrial integrity. Our findings also lay the groundwork for developing novel therapeutic strategies to treat diseases associated with mitochondrial dysfunction. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-22 |
| AnnouncementXML | Submission_2026-08-05_21:46:43.718.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaoyao Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive; Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-22 18:09:28 | ID requested | |
| ⏵ 1 | 2026-08-05 21:46:44 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: AKI, KP1, Klotho, apoptosis, ATAD3A, mitochondrial dysfunction |
Contact List
| Youhua Liu | |
|---|---|
| contact affiliation | Southern Medical University |
| contact email | liuyh@smu.edu.cn |
| lab head | |
| Xiaoyao Zhang | |
| contact affiliation | Southern Medical University |
| contact email | 799012440@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
