PXD072309-1

PXD072309 is an original dataset announced via ProteomeXchange.

Title	Thirty days of supplementation with PQQ reprograms immunometabolic networks in Western diet fed female baboons.
Description	Western-style diets promote chronic metabolic inflammation and dyslipidemia, yet safe interventions that restore immunometabolic homeostasis remain limited. Pyrroloquinoline quinone (PQQ) is a naturally occurring redox cofactor with antioxidant and metabolic regulatory properties, but its systemic effects in translational preclinical models are poorly defined. Here, we examined the impact of short-term PQQ supplementation in obese adult female olive baboons (Papio anubis) chronically fed a Western diet. Using a human-equivalent dose administered for 30 days, we found that PQQ supplementation significantly reduced circulating markers of systemic inflammation and cholesterol in Western-diet fed animals, lowering circulating C-reactive protein, soluble CD163, and atherogenic lipoprotein fractions independent of changes in adiposity. Proteomic and pathway analyses of circulating proteins in plasma and serum revealed suppression of complement, thrombo-inflammatory, and extracellular matrix remodeling pathways, alongside enhanced lipoprotein assembly, remodeling, and clearance. Network analyses identified restoration of neurotrophic tyrosine kinase receptor 1 (NTRK1) and forkhead box A2 (FOXA2)-regulated signaling as central features of the PQQ response, accompanied by inhibition of pro-fibrotic, xenobiotic, and inflammatory pathways and predicted activation of liver X receptor (LXR) and insulin growth factor (IGF) associated metabolic programs. These findings demonstrate that PQQ rapidly reprograms systemic immunometabolic networks in a nonhuman primate model of diet-induced metabolic stress, highlighting FOXA2 and neurotrophin-associated pathways as novel targets of PQQ’s action.
HostingRepository	PRIDE
AnnounceDate	2026-08-24
AnnouncementXML	Submission_2026-08-24_12:44:31.143.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD072309
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Karen Jonscher
SpeciesList	scientific name: Papio anubis anubis; NCBI TaxID: NEWT:211508;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-22 13:32:18	ID requested
⏵ 1	2026-08-24 12:44:31	announced

10.6019/PXD072309;

submitter keyword: lipid metabolism, inflammation, non human primate,Western diet induced obesity, metabolic health, PQQ

Karen Jonscher
contact affiliation	The University of Oklahoma Health Campus
contact email	karen-jonscher@ou.edu
lab head
Karen Jonscher
contact affiliation	University of Oklahoma Health Campus
contact email	karen-jonscher@ou.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD072309
     1. Label: PRIDE project
     2. Name: Thirty days of supplementation with PQQ reprograms immunometabolic networks in Western diet fed female baboons.