⮝ Full datasets listing
PXD072292-1
PXD072292 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PolG Exonuclease Activity in Cardiomyocytes from Mouse Heart |
| Description | In vivo and human correlation study that identifies how mitochondrial DNA (mtDNA) instability triggers heart failure. By creating a mouse model with impaired cardiac mtDNA repair, this study Integrated Stress Response (ISR) activation and folate metabolism rewiring occur before heart function declines. Mice developed progressive cardiomyopathy and liver damage, providing a vital link between mitochondrial defects and systemic heart failure. To investigate this more broadly, we performed proteomic analysis on LVs from mice at 20, 24 and 28-weeks post-TAM, to gain a more global understanding of the molecular changes occurring in mutant hearts. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-22 |
| AnnouncementXML | Submission_2025-12-22_04:32:56.905.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Greening |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Acetyl |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-22 03:57:11 | ID requested | |
| ⏵ 1 | 2025-12-22 04:32:57 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: heart, Mitochondrial dysfunction, Polymerase Gamma (PolG), heart failure, mitochondria, DatasetType:Proteomics |
Contact List
| David Greening | |
|---|---|
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| lab head | |
| David Greening | |
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100303/ |
