PXD072260-1

PXD072260 is an original dataset announced via ProteomeXchange.

Title	Proteomic Profiling Demonstrates Reduced Cytotoxicity and Enhanced Bioactivity of Quercetin Oxidation Metabolites Relative to the Parent Compound
Description	Quercetin (Q) is a widely consumed dietary flavonoid with multiple reported health benefits, yet its extremely low bioavailability—where circulating levels remain far below physiologically effective concentration raises controversy regarding its true biological relevance. Here, we systematically compared Q with its oxidative product, 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (BZF), naturally present in the dried outer layers of onions, to assess whether this conversion offers functional advantages. The results showed BZF displayed markedly superior antioxidant potential with improved solubility and enhanced cytoprotective effects. Proteomics revealed that BZF confers superior protection through dual regulation, simultaneously enhancing antioxidant defenses and suppressing pro-inflammatory signaling.
HostingRepository	PRIDE
AnnounceDate	2026-03-16
AnnouncementXML	Submission_2026-03-16_08:42:25.879.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue Wang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-21 08:29:49	ID requested
⏵ 1	2026-03-16 08:42:26	announced

Dataset with its publication pending

submitter keyword: toxicity, ATDC5,quercetin, metabolite, protectivity, label-free proteomic

Berta Cillero Pastor
contact affiliation	Cell Biology-Inspired Tissue Engineering, Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6200 MD Maastricht, The Netherlands
contact email	b.cilleropastor@maastrichtuniversity.nl
lab head
Yue Wang
contact affiliation	Maastricht university
contact email	yue.wang@maastrichtuniversity.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD072260

PRIDE project URI

• PRIDE
  1. PXD072260
     1. Label: PRIDE project
     2. Name: Proteomic Profiling Demonstrates Reduced Cytotoxicity and Enhanced Bioactivity of Quercetin Oxidation Metabolites Relative to the Parent Compound