PXD072203 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Higher concentration of extracellular vesicles in plasma from ME/CFS patients, with protein cargo alterations implicating complement and coagulation pathways |
| Description | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying biological cargo and are involved in cell-cell communication. Plasma EVs reflect several disease states and may serve as minimally invasive biomarkers. We characterized the plasma EV profiles of ME/CFS patients (N=49) and healthy controls (N=50), by enriching for EVs by size-exclusion chromatography coupled to high-resolution quantitative proteomics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-10 |
| AnnouncementXML | Submission_2026-09-09_19:22:15.734.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ingrid Maria Erika Ekman Stensland |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF fleX |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-19 05:23:31 | ID requested | |
| ⏵ 1 | 2026-09-09 19:22:16 | announced | |
Publication List
| 10.1016/j.bbrep.2026.102679; |
| Rydland A, Yran ES, Nyman TA, Strand EB, Tr, ø, seid AS, Ø, vsteb, ø R, Heinicke F, Lie BA, Viken MK, Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls. Biochem Biophys Rep, 47():102679(2026) [pubmed] |
Keyword List
| submitter keyword: Myalgic encephalomyelitis/chronic fatigue syndrome, Extracellular vesicles, LC-MS/MS |
Contact List
| Tuula Nyman |
|---|
| contact affiliation | Proteomics core facility, Oslo University Hospital |
| contact email | t.a.nyman@medisin.uio.no |
| lab head | |
| Ingrid Maria Erika Ekman Stensland |
|---|
| contact affiliation | Oslo University hospital |
| contact email | maria.stensland@medisin.uio.no |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072203
- Label: PRIDE project
- Name: Higher concentration of extracellular vesicles in plasma from ME/CFS patients, with protein cargo alterations implicating complement and coagulation pathways
