⮝ Full datasets listing
PXD072163-1
PXD072163 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ketone body B-hydroxybutyrate restores Tau proteostasis via metabolism-independent mechanism |
| Description | Alzheimers disease (AD) and related tauopathies are marked by brain accumulation of pathological Tau aggregates and associated metabolic dysfunction. Metabolic interventions including ketogenic diets, caloric restriction, and exercise have shown promise in ameliorating cognitive impairments in AD, but variable efficacy and issues of compliance and side effects mar their translational potential. A shared molecular feature between these interventions is the induction of ketosis, a metabolic state marked by elevated circulating levels of beta hydroxybutyrate (BHB). Previous studies show BHB administration directly or in the form of a precursor can reproduce and even improve upon the benefits of metabolic interventions, but the molecular mechanism underlying the neuroprotective properties of BHB in AD remains to be elucidated. In the current study, we find that a BHB precursor diet is sufficient to ameliorate Tau pathophysiology in the PS19 mouse model at both the pathological and single-cell levels. Furthermore, using a wide array of in vitro, ex vivo, and in vivo models and the non-canonical enantiomer of BHB, we find that not only does BHB improve Tau proteostasis and reduce Tau aggregation and propagation, but the metabolism of BHB is dispensable to these effects. These data support an alternative model to one widely accepted by the field, that BHB exerts its benefits through the provision of alternative energy, uncovering novel biology of metabolic interventions and positioning the metabolic-independent features of BHB as new therapeutic avenues in neurodegenerative disorders. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-07-16 |
| AnnouncementXML | Submission_2026-07-16_12:08:23.457.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Samuel A Myers |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | unknown modification; unknown modification; unknown modification |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-18 14:14:42 | ID requested | |
| ⏵ 1 | 2026-07-16 12:08:24 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Ketone body, Tau, proteostasis, DatasetType:Proteomics |
Contact List
| Xu Chen | |
|---|---|
| contact affiliation | UCSD |
| contact email | x1chen@health.ucsd.edu |
| lab head | |
| Samuel A Myers | |
| contact affiliation | La Jolla Institute for Immunology |
| contact email | sam@lji.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100283/ |
