PXD072130-1

PXD072130 is an original dataset announced via ProteomeXchange.

Title	Dynamics of S752D MuSK kinase domain
Description	The dynamics of purified MuSK S752D kinase domain was probed by HDX-MS.
HostingRepository	PRIDE
AnnounceDate	2026-08-17
AnnouncementXML	Submission_2026-08-16_16:48:05.895.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuko Tsutsui
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-17 23:12:31	ID requested
⏵ 1	2026-08-16 16:48:06	announced

10.1042/bcj20260159;

Pr, ö, mer JJ, Murphy JW, Lemmon MA, Tsutsui Y, Herbst R, An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation. Biochem J, 483(7):1221-1235(2026) [pubmed]

submitter keyword: kinase domain,HDX-MS, MuSK

Yuko Tsutsui
contact affiliation	Yale Cancer Biology Institute
contact email	yuko.tsutsui@yale.edu
lab head
Yuko Tsutsui
contact affiliation	Yale Cancer Biology Institute
contact email	yuko.tsutsui@yale.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD072130

PRIDE project URI

• PRIDE
  1. PXD072130
     1. Label: PRIDE project
     2. Name: Dynamics of S752D MuSK kinase domain