PXD072128-1

PXD072128 is an original dataset announced via ProteomeXchange.

Title	Plant-Derived Nanovesicles (PDNVs) from Ginkgo biloba Seeds
Description	Plant-derived nanovesicles (PDNVs) were isolated from Ginkgo biloba seed homogenate using differential ultracentrifugation (DUC) followed by density gradient ultracentrifugation (DGUC) with linear and non-linear iodixanol gradients. Nanoparticle tracking analysis (NTA) and cryo-transmission electron microscopy (cryo-TEM) characterized vesicle size, concentration, and morphology. Untargeted mass spectrometry profiled the protein content of distinct PDNV fractions. Ginkgo PDNVs formed a heterogeneous population, including single- and double-bilayer vesicles >50 nm. Proteomics revealed seed storage proteins (legumin, ginnacin) and membrane-associated ATPases, HSP90, catalase, PEPC, and eEF1A. Ginkgo seed-derived PDNVs exhibit promising vascular protective and anti-inflammatory properties, supporting their potential as safe, multifunctional agents for endothelial modulation.
HostingRepository	PRIDE
AnnounceDate	2025-12-18
AnnouncementXML	Submission_2025-12-18_04:15:34.219.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD072128
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Dávid Papp
SpeciesList	scientific name: Ginkgo biloba; NCBI TaxID: NEWT:3311;
ModificationList	iodoacetamide derivatized residue
Instrument	SELECT SERIES Cyclic IMS

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-17 19:56:31	ID requested
⏵ 1	2025-12-18 04:15:34	announced

10.6019/PXD072128;

submitter keyword: proteomics,plant-derived nanovesicles, LC-MS, Ginkgo biloba

Gabriella Pocsfalvi
contact affiliation	Extracellular Vesicles and Mass Spectrometry Laboratory, Institute of Biosciences and BioResources, National Research Council of Italy, 80131 Naples, Italy
contact email	gabriellakatalin.pocsfalvi@cnr.it
lab head
Dávid Papp
contact affiliation	MTA-ELTE Lendület (Momentum) Ion Mobility Mass Spectrometry Research Group
contact email	david.papp@ttk.elte.hu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD072128

PRIDE project URI

• PRIDE
  1. PXD072128
     1. Label: PRIDE project
     2. Name: Plant-Derived Nanovesicles (PDNVs) from Ginkgo biloba Seeds