PXD072006 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic and Phosphoproteomic Signatures of Disease Progression in Unmutated IGHV Chronic Lymphocytic Leukemia |
| Description | Chronic lymphocytic leukemia (CLL) patients with an unmutated (UM) immunoglobulin heavy chain variable region gene (IGHV) typically have poorer prognosis and require earlier treatment compared to those with mutated IGHV. Nevertheless, disease progression among UM-CLL patients is heterogeneous, with some experiencing stable disease and prolonged time to first treatment (TTFT). Because the cellular proteome directly reflects cell function, comprehensive proteomic and phosphoproteomic profiling may improve prediction of progression of UM-CLL and uncover novel biomarkers |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-09 |
| AnnouncementXML | Submission_2026-09-09_02:07:27.212.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD072006 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Benjamin Madden |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse; Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-15 04:02:08 | ID requested | |
| ⏵ 1 | 2026-09-09 02:07:28 | announced | |
Publication List
| 10.6019/PXD072006; |
| 10.1186/s12014-026-09607-2; |
| Tschumper RC, Kay NE, Parikh SA, Rabe KG, Sen P, Pandey A, Kandasamy RK, Jelinek DF, Proteomic and phosphoproteomic signatures of disease progression in unmutated IGHV chronic lymphocytic leukemia. Clin Proteomics, 23(1):(2026) [pubmed] |
Keyword List
| submitter keyword: Phosphoproteomics,Chronic Lymphocytic Leukemia, Disease Progression, Unmutated IGHV, Proteomics |
Contact List
| Diane Jelinek Ph.D. |
|---|
| contact affiliation | Professor of Immunology |
| contact email | Jelinek.Diane@mayo.edu |
| lab head | |
| Benjamin Madden |
|---|
| contact affiliation | Mayo Clinic |
| contact email | madden.benjamin@mayo.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD072006 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072006
- Label: PRIDE project
- Name: Proteomic and Phosphoproteomic Signatures of Disease Progression in Unmutated IGHV Chronic Lymphocytic Leukemia
