⮝ Full datasets listing
PXD071962-1
PXD071962 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ZCCHC4 Promotes Translation of Replication-dependent Histone mRNAs |
| Description | ZCCHC4, which has been identified as the m6A RNA methyltransferase for 28S rRNA, is a novel regulator essential for RD histone mRNA translation. ZCCHC4 exhibits unexpected subcellular localization of cytoplasm besides nucleus and the cytoplasmic ZCCHC4 directly interacts with components of the translation initiation machinery. Depletion of ZCCHC4 reduces global protein translation, particularly the translation of RD histones. This translational impairment leads to insufficient histone supply, chromatin relaxation, and prolongs the S phase of the cell cycle. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-11 |
| AnnouncementXML | Submission_2026-07-28_02:20:37.732.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Chen |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue; TMT6plex reporter fragment |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-13 23:14:25 | ID requested | |
| ⏵ 1 | 2026-07-28 02:20:38 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: RNA methyltransferase, mRNA translation, Histone synthesis |
Contact List
| Hao Chen | |
|---|---|
| contact affiliation | Southern University of Science and Technology |
| contact email | chenh7@sustech.edu.cn |
| lab head | |
| Hao Chen | |
| contact affiliation | Southern University of Science and Technology |
| contact email | chenh7@sustech.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
