PXD071928 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mass Spectrometry Footprinting Reveals How Kinetic Stabilizers Counteract Transthyretin Dynamics Altered by Pathogenic Mutations_FPOP |
| Description | Transthyretin (TTR) aggregation causes transthyretin amyloidosis, a severe condition often linked to mutations that destabilize the TTR tetramer, leading to amyloid fibril formation. Small molecules that stabilize the tetramer can prevent this process. While over 300 X-ray structures of TTR exist, they represent static snapshots and fail to show dynamic changes from mutations or ligand binding. This project uses hydrogen-deuterium exchange (HDX) and fast photochemical oxidation of proteins (FPOP) with mass spectrometry (MS) to study these conformational dynamics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-13 |
| AnnouncementXML | Submission_2025-12-13_04:32:18.476.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | RAVI KANT |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-12 12:47:54 | ID requested | |
| ⏵ 1 | 2025-12-13 04:32:18 | announced | |
Publication List
Keyword List
| submitter keyword: transthyretin, fast photochemical oxidation of proteins (FPOP),protein dynamics, 37 hydrogen/deuterium exchange mass spectrometry (HDX-MS) |
Contact List
| Dr. Michael L. Gross |
|---|
| contact affiliation | Professor of Chemistry, Immunology, Medicine Department of Chemistry, MSC 1134-196-525 Washington University in St. Louis One Brookings Drive St. Louis, Mo 63130 Phone: 314-935-4814; Fax: 314-935-7484 Dept: https://chemistry.wustl.edu/people/michael-l-gross Lab: https://mgrosslab.com/ |
| contact email | mgross@wustl.edu |
| lab head | |
| RAVI KANT |
|---|
| contact affiliation | WASHINGTON UNIVERSITY IN SAINT LOUIS |
| contact email | ravi.kant@wustl.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD071928 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071928
- Label: PRIDE project
- Name: Mass Spectrometry Footprinting Reveals How Kinetic Stabilizers Counteract Transthyretin Dynamics Altered by Pathogenic Mutations_FPOP
