⮝ Full datasets listing
PXD071798-1
PXD071798 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Loss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells |
| Description | Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we found p53 expression was significantly reduced in Treg cells negatively correlating with abnormally elevated BCL-6 levels. p53 loss causes dysregulated immune homeostasis and dampens Tregs function in vitro and in vivo. Mechanistically, p53 transcriptionally activates ALDH6A1 expression and propionyl-CoA anabolism to upregulate functional Treg gene expression via histone propionylation. Treg-specific knockout of ALDH6A1 phenocopies the autoimmune responses of p53 deficiency, and propionyl-CoA restoration recovers Treg cell function in mice lacking p53 or ALDH6A1. Clinically, impaired p53-ALDH6A1-histone propionylation signaling is observed in AS and SLE patients and correlates with poor efficacy of first-line therapies in autoimmune patients. Together, these findings reveal a directly connection between propionyl-CoA metabolism and epigenetic changes, which is governed by p53 and is crucial for Treg cell function and immune tolerance suppression. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-10 |
| AnnouncementXML | Submission_2026-01-28_19:01:36.516.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Siyi Xie |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-09 22:56:02 | ID requested | |
| ⏵ 1 | 2026-01-28 19:01:37 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Treg cell function, p53, propionyl-CoA anabolism, autoimmune response, histone propionylation |
Contact List
| Peng Jiang | |
|---|---|
| contact affiliation | Tsinghua University |
| contact email | 823678584@qq.com |
| lab head | |
| Siyi Xie | |
| contact affiliation | Tsinghua University |
| contact email | 823678584@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
