PXD071776 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Repurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology |
| Description | Drug repurposing offers a cost-effective strategy for accelerating therapeutic development. This study identifies trazodone, an FDA-approved anti-depressant, as a promising therapeutic candidate for Alzheimer’s disease (AD). We show that trazodone use in patients with AD is associated with decreased levels of soluble ST2 (sST2), a known disease-modifying factor in AD. In the APP/PS1 transgenic mouse model of AD, trazodone treatment enhances microglial interactions with amyloid-beta (Aβ) and alleviates Aβ pathology. Additionally, trazodone rescues synaptic deficits and restores the expression of synaptic proteins in APP/PS1 mice. These findings demonstrate the therapeutic potential of repurposing trazodone to target immune and synaptic dysfunctions in AD, providing a novel therapeutic avenue for this debilitating condition. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-02 |
| AnnouncementXML | Submission_2026-07-01_18:50:32.170.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Daniel Yew Kit Wong |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-09 12:25:55 | ID requested | |
| ⏵ 1 | 2026-07-01 18:50:32 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
Contact List
| Nancy Yuk-Yu |
|---|
| contact affiliation | Room 6313, Academic building, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon |
| contact email | iplabgenetics@gmail.com |
| lab head | |
| Daniel Yew Kit Wong |
|---|
| contact affiliation | Hong Kong University of Science and Technology |
| contact email | ykdwong@connect.ust.hk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD071776 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071776
- Label: PRIDE project
- Name: Repurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology
