PXD071747-1

PXD071747 is an original dataset announced via ProteomeXchange.

Title	Discovery and Validation of Serum ROBO4 and VCAM-1 as Diagnostic and Prognostic Biomarkers for Colorectal Cancer via Proteomics
Description	This project encompasses the serum proteomic data generated for the discovery of novel biomarkers for colorectal cancer (CRC). Utilizing data-independent acquisition (DIA) mass spectrometry, we comprehensively profiled the proteomes of serum samples from individuals with CRC, colorectal adenoma, and healthy controls. The analysis identified a panel of significantly dysregulated proteins, highlighting altered pathways in CRC pathogenesis. From this, ROBO4 and VCAM-1 were selected as top candidate biomarkers based on their significant differential expression and relevance to cancer biology. This dataset provides a valuable resource for exploring the serum protein landscape in colorectal carcinogenesis and for the discovery of diagnostic signatures.
HostingRepository	iProX
AnnounceDate	2025-12-09
AnnouncementXML	Submission_2025-12-31_00:23:34.743.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bizhu Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-08 23:30:13	ID requested
⏵ 1	2025-12-31 00:23:35	announced

Dataset with its publication pending

submitter keyword: colorectal cancer, serum proteomics, biomarker, DIA, diagnosis, prognosis, ROBO4, VCAM-1

Bin Zhang
contact affiliation	The First Affiliated Hospital of Hebei North University
contact email	zbzb612@126.com
lab head
Bizhu Zhang
contact affiliation	The First Affiliated Hospital of Hebei North University
contact email	cadina2025@163.com
dataset submitter

iProX dataset URI