PXD071700-1

PXD071700 is an original dataset announced via ProteomeXchange.

Title	Coro1a promotes the multivesicular body and plasma membrane fusion by facilitating PKM2-mediated SNAP-23 phosphorylation
Description	During the formation of endosomal pathway-dependent extracellular vesicles (EVs), intraluminal vesicles in multivesicular bodies (MVBs) fuse with the plasma membrane (PM), releasing intraluminal vesicles to produce exosomes. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, membrane fusion effector, is essential in this process. However, which SNARE complex is involved in MVB and PM fusion and how its assembly is regulated remain elusive. We have demonstrated that neddylation of Coro1a inhibits EV secretion by inducing Rab7-mediated degradation of MVBs. Here, we find that Coro1a increases EV biogenesis by promoting the assembly of SNARE complex STX-12-SNAP-23-VAMP-7 in a neddylation-independent manner.
HostingRepository	iProX
AnnounceDate	2025-12-07
AnnouncementXML	Submission_2025-12-07_19:02:52.372.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xianghui Kong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-07 19:02:24	ID requested
⏵ 1	2025-12-07 19:02:52	announced

Dataset with its publication pending

submitter keyword: Extracellular vesicles, exosomes

Coro1a, SNARE complex

Zhiajian Cai
contact affiliation	Zhejiang University
contact email	caizj@zju.edu.cn
lab head
Xianghui Kong
contact affiliation	Zhejiang University
contact email	kuem17@zju.edu.cn
dataset submitter

iProX dataset URI