⮝ Full datasets listing
PXD071619-1
PXD071619 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of Novel Biomolecular Characteristics and Bioinformatic Analyses of the Anterior Cingulate Cortex in Morphine-Dependent Mice via Proteomic Profiling |
| Description | Impaired function of the anterior cingulate cortex (ACC) is widely recognized as a critical factor in drug dependence. This study aimed to investigate protein alterations in the ACC of morphine-dependent mice using 4D label-free quantitative proteomics. Procrustes analysis and Pearson correlation analysis of the differentially expressed proteins (DEPs) and behavioral phenotypes identified 81 DEPs (p-value < 0.05). Advanced bioinformatics analysis of these DEPs suggested dysregulation of several biological pathways in the ACC of morphine-dependent mice, including mitochondrial energy metabolism, endoplasmic reticulum-to-nucleus signaling, inhibitory synapse assembly, and intracellular trafficking, secretion, and vesicle-mediated transport. These findings provide a basis for understanding the proteomic alterations and offer an integrated perspective on the biomolecular changes in the ACC associated with morphine dependence. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-05 |
| AnnouncementXML | Submission_2025-12-04_22:49:32.761.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Junxia Yang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-04 22:49:19 | ID requested | |
| ⏵ 1 | 2025-12-04 22:49:33 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Morphine dependence, Anterior cingulate cortex, Proteomics profiling, Differentially expressed proteins (DEPs) |
Contact List
| Junxia Yang | |
|---|---|
| contact affiliation | Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, China NMPA Key Laboratory for Research |
| contact email | yjx001011@163.com |
| lab head | |
| Junxia Yang | |
| contact affiliation | Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, China NMPA Key Laboratory for Research |
| contact email | yjx001011@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
