PXD071596-2

PXD071596 is an original dataset announced via ProteomeXchange.

Title	A HUWE1 Regulatory Helix Gates ASCL1 Degradation through Its C-Terminal Phospho-Degron in Small Cell Lung Cancer
Description	The goal of this project was to understand the regulation of ASCL1 by HUWE1, an E3 ligase. Proteomic methodologies were used to confirm the regulation of ASCL1 levels by HUWE1.
HostingRepository	PRIDE
AnnounceDate	2026-08-03
AnnouncementXML	Submission_2026-08-03_14:04:14.988.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD071596
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kevin Dong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-04 15:56:50	ID requested
1	2026-08-03 13:59:56	announced
⏵ 2	2026-08-03 14:04:15	announced	2026-08-03: Updated project metadata.

10.6019/PXD071596;

submitter keyword: whole proteome,TMT

Kevin Dong
contact affiliation	Harvard Medical School
contact email	kevindong@g.harvard.edu
lab head
Kevin Dong
contact affiliation	Harvard Medical School
contact email	kevindong@g.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD071596

PRIDE project URI

• PRIDE
  1. PXD071596
     1. Label: PRIDE project
     2. Name: A HUWE1 Regulatory Helix Gates ASCL1 Degradation through Its C-Terminal Phospho-Degron in Small Cell Lung Cancer