⮝ Full datasets listing
PXD071578-1
PXD071578 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Age-Dependent Effects of Fibroblast-Derived Exosomes on Keratinocyte Differentiation |
| Description | Skin aging is driven by both extrinsic factors, such as ultraviolet exposure, and intrinsic, chronological processes that lead to progressive deterioration in skin homeostasis and structure. Chronological aging is associated with replicative senescence and a range of molecular and cellular alterations, including genomic instability, mitochondrial dysfunction, and impaired intercellular communication. The dynamic cross-talk between dermal fibroblasts and epidermal keratinocytes is crucial for maintaining skin integrity throughout aging, with extracellular vesicles (EVs) emerging as key mediators of this intercellular communication. While the impact of keratinocyte-derived EVs in modulating dermal fibroblast function is increasingly recognized, the reciprocal influence of fibroblast-derived EVs on keratinocytes remains largely unexplored, particularly in the context of aging. In this study, we isolated and characterized small EVs, mainly exosomes, from primary human dermal fibroblasts derived from young and aged donors. We analyzed their size, molecular composition, and age-related differences, and assessed their effects on keratinocyte function. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-04-01 |
| AnnouncementXML | Submission_2026-04-01_08:42:08.530.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Page |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | TMT6plex; Oxidation |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-04 07:38:15 | ID requested | |
| ⏵ 1 | 2026-04-01 08:42:09 | announced |
Publication List
| Rorteau J, Bechetoille N, Lamartine J, Age-dependent effects of fibroblast-derived exosomes on keratinocyte differentiation. Biogerontology, 27(2):(2026) [pubmed] |
Keyword List
| submitter keyword: aging, skin, extracellular vesicles, keratinocytes, fibroblasts, DatasetType:Proteomics |
Contact List
| Jerome LAMARTINE | |
|---|---|
| contact affiliation | LBTI CNRS UMR5305 University Lyon I |
| contact email | jerome.lamartine@univ-lyon1.fr |
| lab head | |
| Page | |
| contact affiliation | CNRS |
| contact email | adeline.page@ibcp.fr |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100099/ |
