PXD071538-1

PXD071538 is an original dataset announced via ProteomeXchange.

Title	Liver-metastases restrict IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer
Description	To see how the secretome changes upon challenging organoids with immune pressure, we wanted to perform secretomics on CRC MSI organoids +- stimulation with IFNy. Secretomics was performed using a previously published metabolic labeling method based on threonine-derived non-canonical amino acid tagging (THRONCAT) [1].
HostingRepository	PRIDE
AnnounceDate	2025-12-09
AnnouncementXML	Submission_2025-12-09_15:46:03.082.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Onno Bleijerveld
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-03 09:53:05	ID requested
⏵ 1	2025-12-09 15:46:03	announced

Dataset with its publication pending

submitter keyword: None

Onno Bleijerveld
contact affiliation	The Netherlands Cancer Institute Proteomics Facility
contact email	o.bleijerveld@nki.nl
lab head
Onno Bleijerveld
contact affiliation	The Netherlands Cancer Institute
contact email	o.bleijerveld@nki.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD071538

PRIDE project URI

• PRIDE
  1. PXD071538
     1. Label: PRIDE project
     2. Name: Liver-metastases restrict IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer