PXD071497 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia |
| Description | This dataset profiles the proteomic effects of altering BAP1 expression in human trophoblast stem cells and trophoblast organoids. Samples from control, BAP1-overexpressing, and BAP1-knockdown conditions were analyzed by LC–MS/MS. DIA-NN–based quantification and differential analysis revealed BAP1-dependent changes affecting trophoblast differentiation, inflammatory signaling, and pathways linked to early-onset preeclampsia. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-24 |
| AnnouncementXML | Submission_2026-03-24_06:52:22.225.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sergio Navarro |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF fleX |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-02 18:11:40 | ID requested | |
| ⏵ 1 | 2026-03-24 06:52:22 | announced | |
Publication List
Keyword List
| submitter keyword: organoids, trophoblast,BAP1, early-onset preeclampsia, placenta |
Contact List
| Vicente Perez-Garcia |
|---|
| contact affiliation | Centro de Biología Molecular (CBM) |
| contact email | vperez@cbm.csic.es |
| lab head | |
| Sergio Navarro |
|---|
| contact affiliation | Centro de Biología Molecular (CBM) |
| contact email | sergio.navarro@cbm.csic.es |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD071497 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071497
- Label: PRIDE project
- Name: BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia
