⮝ Full datasets listing
PXD071407-1
PXD071407 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Antifungal mechanism of Galla chinensis against Candida albicans by disrupting extracellular vesicles-mediated trafficking |
| Description | Targeting extracellular vesicles (EVs) of Candida albicans as the main pathogen of oral candidiasis, has been proved to be a promising strategy to reduce its drug resistance and virulence. However, the effect mechanism of traditional Chinese medicine Galla chinensis on the fungi remains unclear. Our investigation indicated that aqueous extract of G. chinensis (GCE) exhibited powerful antifungal activities on cell growth and viability, and significantly impaired its ultrastructure, biofilm formation and morphogenesis of C. albicans. Besides, GCE markedly decreased EVs particle concentration by 94% and disrupted the assembly of approximately two-thirds of cargo proteins involved in the pathways of translation and energy metabolism. It significantly downregulated the transcription of genes associated with biofilm formation, hyphal morphogenesis, and virulence, such as Tec1, Bcr1, Hwp1, Cht3, Tos1, Sap6, and Als1. Its effect mechanism is to disrupt EVs-mediated trafficking of cargo proteins, and impair the multi-targets or biological processes including cell growth, and hyphal morphogenesis and biofilm formation of C. albicans and relieved drug resistance. Therefore, GCE is a promising antifungal drug or a vesicle inhibitor for C. albicans. This research makes obvious contribution to a profound understanding of therapeutic mechanism of natural medicine G. chinensis on oral candidiasis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-29 |
| AnnouncementXML | Submission_2025-11-30_23:29:22.795.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Daixi Zhang |
| SpeciesList | scientific name: Candida albicans; NCBI TaxID: 5476; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-30 23:28:59 | ID requested | |
| ⏵ 1 | 2025-11-30 23:29:23 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Galla chinensis, Candida albicans, extracellular vesicle, antifungal, TCM |
Contact List
| Daixi Zhang | |
|---|---|
| contact affiliation | Chengdu University of Traditional Chinese Medicine |
| contact email | zhangdaixi@cdutcm.edu.cn |
| lab head | |
| Daixi Zhang | |
| contact affiliation | Chengdu University of Traditional Chinese Medicine |
| contact email | zhangdaixi@cdutcm.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
