PXD071373 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chromatin-associated protein networks of CEBPA and SUMO2/3 identified with RIME |
| Description | We identified the chromatin-associated protein networks of CEBPA and SUMO2/3 in BLaER1 cells during the early stages of B-cell-to-macrophage transdifferentiation. Additionally, we studied the impact of SUMOylation inhibition (SUMOi) on CEBPA protein network composition utilizing the small molecule inhibitor ML-792. Protein network members were identified with Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins (RIME) at 0, 6 and 24 h after induction of transdifferentiation in the absence and presence of ML-792. Mass spectrometry analyses were executed with high resolution mass spectrometry (LC-MS), using the Evosep One liquid chromatography system coupled to a hybrid trapped ion mobility quadrupole TOF mass spectrometer (Bruker timsTOF Pro) via a CaptiveSpray nano-electrospray ion source. High-confidence chromatome members were discriminated from background with SAINT analysis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-27 |
| AnnouncementXML | Submission_2026-05-27_08:56:20.530.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Emma Valima |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | biotinylated residue; acetylated residue; monohydroxylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-28 10:14:17 | ID requested | |
| ⏵ 1 | 2026-05-27 08:56:21 | announced | |
Publication List
Keyword List
| submitter keyword: mass spectrometry, transdifferentiation, immunoprecipitation,human, chromatin |
Contact List
| Jorma J. Palvimo |
|---|
| contact affiliation | Institute of Biomedicine, School of Medicine, University of Eastern Finland, Finland |
| contact email | jorma.palvimo@uef.fi |
| lab head | |
| Emma Valima |
|---|
| contact affiliation | Institute of Biomedicine, School of Medicine, University of Eastern Finland |
| contact email | emma.valima@uef.fi |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071373
- Label: PRIDE project
- Name: Chromatin-associated protein networks of CEBPA and SUMO2/3 identified with RIME
