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PXD071353-1
PXD071353 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative Analysis of Age-dependent Albumin Modifications |
| Description | Albumin, the most abundant plasma protein, plays critical roles in blood homeostasis by maintaining osmotic pressure, transporting diverse substances, and providing antioxidant defense. The function and regulation of albumin are influenced by its post-translational modifications (PTMs), yet how these modifications change with age remains incompletely understood. In the present study, we employed tandem mass spectrometry to quantitatively profile PTMs of human plasma albumin across different age groups. Specially, we characterized the redox state of Cys34, oxidation of methionine residues, the presence of the C-terminal cleavage product, and glycation of lysine residues. Our results showed that the reduced-to-oxidized ratio of Cys34 was approximately 40% higher in plasma from donors under 40 years old compared to older individuals. Consistently, oxidation of methionine residues（Met123, Met298, Met446 and Met548）was significantly increased with age. We also observed an age-dependent rise in intact C-terminal albumin and glycation of lysine residues (K64, K137, k262 and K525). Together, these findings provide a comprehensive profile of albumin modifications during aging and highlight potential biomarkers for tracking aging and its related health conditions. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-28 |
| AnnouncementXML | Submission_2025-11-28_01:03:37.567.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Han Meng |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-28 01:03:13 | ID requested | |
| ⏵ 1 | 2025-11-28 01:03:38 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: albumin, redox status, aging, Cys34 oxidation |
Contact List
| Haiteng Deng | |
|---|---|
| contact affiliation | Tsinghua University |
| contact email | dht@mail.tsinghua.edu.cn |
| lab head | |
| Han Meng | |
| contact affiliation | Tsinghua University |
| contact email | hanmeng@mail.tsinghua.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
