⮝ Full datasets listing
PXD071347-1
PXD071347 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Novel SLCO2B1 mRNA isoform acts as a noncoding RNA and drives cancer progression through FMR1-mediated protein biosynthesis |
| Description | The eukaryotic 5’ untranslated region (5’ UTR) canonically influences mRNA translation efficiency. However, the role of the 5’ UTR structure in blocking mRNA translation and turning a coding RNA into a noncoding RNA remains undocumented. Herein, we discovered a novel mRNA isoform of the human solute carrier organic anion transporter family member 2B1 (SLCO2B1) gene, named SLCO2B1-isoformNovel (SLCO2B1-isoN), whose 5’ end stem‒loop abrogates its translational capacity and turns it into a noncoding RNA. The SLCO2B1-isoN noncoding isoform stabilizes fragile X messenger ribonucleoprotein 1 (FMR1) to trigger hepatocellular carcinoma (HCC) progression by facilitating de novo protein biosynthesis. Targeting SLCO2B1-isoN effectively inhibited orthotopic tumor xenograft growth in vivo. In conclusion, this study revealed a previously unrecognized noncoding isoform of SLCO2B1 mRNA with a 5’ end stem‒loop structure and highlighted the dual characteristics of mRNAs harboring protein-coding and noncoding isoforms, providing new insights into the richness of genetic information in protein-coding genes. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-27 |
| AnnouncementXML | Submission_2025-11-27_19:56:46.363.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wenying Qiu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-27 19:56:33 | ID requested | |
| ⏵ 1 | 2025-11-27 19:56:46 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: SLCO2B1-isoN, RNA pull-down, LC-MS/MS |
Contact List
| Xianghuo He | |
|---|---|
| contact affiliation | Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences |
| contact email | xhhe@fudan.edu.cn |
| lab head | |
| Wenying Qiu | |
| contact affiliation | Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences |
| contact email | wenyingq1999@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
