⮝ Full datasets listing
PXD071297-1
PXD071297 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Engineering functional nanovesicles using hypoxic conditioning of human pluripotent stem cell |
| Description | As biomimetic extracellular vesicles, cell-derived nanovesicles (NVs) have emerged as scalable high-yield platforms and important mediators of intercellular communication, drug delivery devices and in therapeutic applications, including regenerative biology. However, improving their potency through various engineering strategies has presented challenges. Here, hypoxic predicitioning on human induced pluripotent stem cells (iPSC) was analysed as an engineering strategy to impact composition and potency of generated NVs. Temporally, we performed adaptive cellular remodelling of iPSCS to hypoxic pre-conditioning (2-6 hr), demonstrating NV form and composition is context dependent on hypoxia and its duration. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-10 |
| AnnouncementXML | Submission_2025-12-10_21:00:43.232.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Greening |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-26 19:26:03 | ID requested | |
| ⏵ 1 | 2025-12-10 21:00:43 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: stem cells, nanovesicles, bioengineering, DatasetType:Proteomics |
Contact List
| David Greening | |
|---|---|
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| lab head | |
| David Greening | |
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100040/ |
