⮝ Full datasets listing
PXD071237-1
PXD071237 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-phase hybrid metabolomics framework identifies clinically applicable plasma signatures for early detection of gastric cancer |
| Description | Plasma metabolomics offers significant potential for non-invasive biomarker discovery in gastric cancer (GC), yet conventional analytical workflows face challenges in absolute quantification and biological interpretability, hindering clinical translation. We present an innovative multi-phase hybrid framework integrating untargeted metabolomics with relative- and absolute-quantitative targeted metabolomics, coupled with a custom interpretability-driven algorithm for de novo biomarker identification. Metabolic profiling was performed using 1,706 plasma samples from multicenter cohorts. The relative-quantitation phase identified 84 key metabolites significantly enriched in caffeine metabolism and primary bile acid biosynthesis pathways. By applying the custom algorithm to absolute quantitation data, we established a 12-metabolite panel covering multiple functional metabolic modules. Machine learning-based diagnostic models using this signature achieved an area under the curve of 0.951 in validation cohort. Together, our study provides a robust and interpretable framework for translational metabolomics and establishes a GC detection biomarker panel, laying the foundation for future mechanistic research and clinical application. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-24 |
| AnnouncementXML | Submission_2026-04-19_17:09:23.887.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Liyi Bai |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | QTRAP 6500+ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-25 18:09:09 | ID requested | |
| ⏵ 1 | 2026-04-19 17:09:24 | announced | |
| 2 | 2026-06-03 01:56:42 | announced | 2026-06-03: Add info |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: plasma, metabolomic, noninvasive, biomarker, gastric cancer |
Contact List
| Min Li | |
|---|---|
| contact affiliation | Beijing Friendship Hospital, Capital Medical University |
| contact email | minli@ccmu.edu.cn |
| lab head | |
| Liyi Bai | |
| contact affiliation | Beijing Friendship Hospital, Capital Medical University |
| contact email | baily@ccmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
