PXD071192-1

PXD071192 is an original dataset announced via ProteomeXchange.

Title	Effect of depression and serotonin reuptake inhibitors antidepressant treatment during pregnancy on protein expression in the human placenta: A quantitative proteomics analysis
Description	## Overview This dataset contains mass spectrometry-based proteomics results from term placenta tissue specimens collected at birth from a cohort of pregnant individuals. The aim was to characterize placental protein expression in relation to maternal depressive symptoms and Selective Serotonin Reuptake Inhibitor (SSRI) treatment during the antenatal period. ## Project Details ### Participants and Sample Stratification Placenta tissue samples were collected from pregnant individuals in metropolitan Vancouver, Canada, as part of an ethically approved observational cohort study (University of British Columbia/Children’s and Women’s Research Ethics Board: H12-00733, H16-02280). Written informed consent was obtained from all participants, and study procedures complied with the Helsinki Declaration (2008 revision). Depressive symptoms were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Hamilton Depression Rating Scale (HAM-D) at recruitment and at 36 weeks gestation. Group assignment was determined as follows: - Symptomatic depression: HAM-D score ≥ 8 at 36 weeks gestation - Control group: HAM-D < 8 and no SSRI treatment - Three groups included: (1) Controls, (2) Mild/moderate depressive symptoms without SSRI, (3) Mild/moderate depressive symptoms with SSRI Participants exposed to SSRIs (fluoxetine, paroxetine, sertraline, citalopram, or escitalopram) received treatment for at least 75 days prior to delivery, with adherence monitored throughout pregnancy. Individuals meeting exclusion criteria (medical/psychiatric conditions other than unipolar depression/anxiety, substance abuse, gestational hypertension, diabetes, placental insufficiency, fetal anomaly, intrauterine growth restriction) were not included. **The final dataset comprises 70 placenta samples
HostingRepository	PRIDE
AnnounceDate	2025-12-22
AnnouncementXML	Submission_2025-12-21_17:27:31.870.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cathy Vaillancourt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-25 06:40:48	ID requested
⏵ 1	2025-12-21 17:27:32	announced

10.1371/journal.pone.0322090;

Ok L, Ohlund L, Inkster AM, Campbell KSJ, Pe, ñ, aherrera MS, Brain U, Sleno L, Robinson WP, Barry A, Oberlander TF, Vaillancourt C, Effect of depression and serotonin reuptake inhibitors antidepressant treatment during pregnancy on protein expression in the human placenta: A quantitative proteomics analysis. PLoS One, 20(12):e0322090(2025) [pubmed]

submitter keyword: Human, Placenta, LC-MS-MS

Cathy Vaillancourt
contact affiliation	Institut national de la recherche scientifique(INRS)-Centre Armand Frappier Santé Biotechnologie
contact email	cathy.vaillancourt@inrs.ca
lab head
Cathy Vaillancourt
contact affiliation	Institut national de la recherche scientifique (INRS), Centre Armand-Frappier Santé Biotechnologie
contact email	cathy.vaillancourt@inrs.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD071192

PRIDE project URI

• PRIDE
  1. PXD071192
     1. Label: PRIDE project
     2. Name: Effect of depression and serotonin reuptake inhibitors antidepressant treatment during pregnancy on protein expression in the human placenta: A quantitative proteomics analysis