PXD071155-1

PXD071155 is an original dataset announced via ProteomeXchange.

Title	NCI-7 cell line and individual cell line proteome
Description	Protein characterization of cancer proteins is vital for advancing cancer research, serving as foundational resources in integrative multi-omics studies. Recently, significant progress has been made in expanding the mass spectrometry-based proteomics and detecting cancer proteins with a particular focus on addressing gaps in protein identification and enhancing data accessibility. However, the accessibility of cancer proteins is limited. In this study, we report advancements in the development of integrated datasets of mass spectrometric detected cancer proteins database (MSCPDIDMSCP) from recent proteomics characterization of major cohorts of human tumor tissues, normal adjacent to tumors (NATs), Patient-Derived Xenograft (PDX) models, and human cancer cell lines. We also compare this cancer proteomic database with previously reported human proteomic databases, such as UniProt Knowledgebase (UniProtKB) and the neXtProt knowledgebase (neXtProt), for complementary analysis. Enhanced database analysis and statistical validation of protein sources have contributed to the detection of 15,737 cancer proteins in the human proteome. These advancements are supported by robust platforms for mass spectrometry, data mining, annotation, and validation, ensuring high-confidence discoveries that contributed by the diversity of cancer cohorts. The MSCPD provides the first public accessible database for cancer proteins identified from different cancer tissues and cells, serving as resource for cancer research.
HostingRepository	PRIDE
AnnounceDate	2026-05-01
AnnouncementXML	Submission_2026-05-01_14:42:25.157.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuanyu Huang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-24 15:36:24	ID requested
⏵ 1	2026-05-01 14:42:26	announced

10.1021/acs.jproteome.5c01259;

Huang Y, Chen L, Wu PI, Juneja P, Chen L, Evrard YA, Jiao L, Hu Y, Zhang X, Doroshow JH, Thangudu RR, Pilozzi A, Zhang H, Mass Spectrometric Detected Cancer Proteins as Resources for Cancer Research. J Proteome Res, 25(6):2901-2914(2026) [pubmed]

submitter keyword: Human, cell line, LC-MS/MS

Hui Zhang
contact affiliation	Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States
contact email	huizhang@jhu.edu
lab head
Yuanyu Huang
contact affiliation	Johns Hopkins University
contact email	yhuan295@jh.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD071155

PRIDE project URI

• PRIDE
  1. PXD071155
     1. Label: PRIDE project
     2. Name: NCI-7 cell line and individual cell line proteome