⮝ Full datasets listing
PXD071153-1
PXD071153 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters |
| Description | MGRN1, a membrane-anchored E3 ligase, uses multiple transmembrane adapters-including newly identified ATRN and ATRNL1-to target specific surface receptors for ubiquitination and degradation. These adapters bind the RING domain of MGRN1 and enable it to regulate melanocortin receptors MC1R and MC4R in a manner similar to its known control of Smoothened. Loss of MGRN1 increases surface levels of these receptors and boosts eumelanin production, revealing an expanded and unifying mechanism for receptor-specific regulation by membrane-tethered E3 ligases. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-02 |
| AnnouncementXML | Submission_2025-12-02_17:12:52.182.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Michael Riffle |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Oxidation; Phospho |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-24 15:04:32 | ID requested | |
| ⏵ 1 | 2025-12-02 17:12:52 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: MGRN1, E3 ubiquitin ligase, transmembrane, transmembrane adapter proteins, melanocortin receptors, GPCR trafficking, DatasetType:Proteomics |
Contact List
| Jennifer Kong | |
|---|---|
| contact affiliation | University of Washington |
| contact email | jennkong@uw.edu |
| lab head | |
| Michael Riffle | |
| contact affiliation | University of Washington |
| contact email | mriffle@uw.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100009/ |
