PXD071150 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cohesin loop extrusion tethers DNA replication forks to drive their slowing and reversal |
| Description | DNA replication forks challenged by genotoxic agents have a high degree of plasticity to ensure their stability, allowing replicative tolerance and complete genome duplication. How genome architectural factors influence this response is less understood. We have investigated the role of cohesin and its different functions by the use auxin-inducible degrons (AID) and separation of function mutants. With a newly-develop Micro-C based technique to capture chromatin contacts at nascent DNA (Repli-C), we describe that cohesin loop extrusion helps connecting adjacent replication forks belonging to different replication origins. This process promotes replication fork reversal by preventing unscheduled PrimPol action at replication forks. These findings reveal how tethering of distant replication fork influences fork plasticity and genome stability. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-05 |
| AnnouncementXML | Submission_2026-08-05_04:42:15.517.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Orhi Barroso Gomila |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-24 14:31:30 | ID requested | |
| ⏵ 1 | 2026-08-05 04:42:16 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: iPOND, Replication fork,Cohesin |
Contact List
| Daniel González-Acosta |
|---|
| contact affiliation | Institute of Molecular Cancer Research (IMCR), University of Zürich; Zürich, CH-8057, Switzerland |
| contact email | gonzalez@imcr.uzh.ch |
| lab head | |
| Orhi Barroso Gomila |
|---|
| contact affiliation | IIS Biobizkaia |
| contact email | orhi.barrosogomila@bio-bizkaia.eus |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD071150 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071150
- Label: PRIDE project
- Name: Cohesin loop extrusion tethers DNA replication forks to drive their slowing and reversal
